Environment Canada warned that strong winds and heavy snowfall could strike Central British Columbia on Friday and Saturday.
It also warned that drivers should be extra careful.
Warnings have been issued for several regions of the province on Thursday.
About 15 to 25 centimeters of snow is estimated to fall on the Cariboo and Peace River regions and along areas of the B.C.-Alberta border.
Williams Lake, Quesnel, Prince George as well as key routes including the highway 97 and Yellowhead highway may possibly see considerable snowfall.
As forecasted by the system, along with snow, it will bring strong winds which could reduce visibility.
The weather system is expected to strike B.C. Friday morning, and blow into Alberta and last until Saturday.